HISTOLOGICAL CHANGES IN RAT LIVER AFTER CHRONIC IRON-SORBITOL OVERLOAD
نویسندگان
چکیده
منابع مشابه
Chronic iron overload enhances inducible nitric oxide synthase expression in rat liver.
Iron is an essential micronutrient promoting oxidative stress in the liver of overloaded animals and human, which may trigger the expression of redox-sensitive genes. We have tested the hypothesis that chronic iron overload (CIO) enhances inducible nitric oxide synthase (iNOS) expression in rat liver by extracellular signal-regulated kinase (ERK1/2) and NF-kappaB activation. CIO (diet enriched ...
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Iron overload has been measured in 100 hepatic biopsies by three different methods: (i) biochemical assay of the liver iron concentration (LIC), (ii) histological grading (HISTO) and (iii) automated image analysis with a Leitz Texture Analysis System by estimating two parameters, (a) the total iron area (TIA) and (b) the first grey level step (FGLS) at which the iron is detected. Image analysis...
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The liver plays a major role in iron homeostasis; thus, in patients with chronic liver disease, iron regulation may be disturbed. Higher iron levels are present not only in patients with hereditary hemochromatosis, but also in those with alcoholic liver disease, nonalcoholic fatty liver disease, and hepatitis C viral infection. Chronic liver disease decreases the synthetic functions of the live...
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BACKGROUND Recently it has been found that iron is an important element in the natural history of hepatitis C. Serum markers of iron stores are frequently increased in chronic hepatitis C virus (HCV)-infected carriers but the real impact of the hepatic iron overload is poorly understood. The purpose of the present paper was to determine the prevalence of iron overload and to study the relations...
متن کاملco-administration of silymarin and deferoxamine against kidney, liver and heart iron deposition in male iron overload rat model
background: tissue iron deposition may disturb functions of the organs. in many diseases like thalassemia, the patients suffer from iron deposition in kidney and heart tissues. deferoxamine (df) is a synthetic iron chelator and silymarin (sm) is an antioxidant and also a candidate for iron chelating. this study was designed to investigate the effect of df and sm combination against kidney and h...
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ژورنال
عنوان ژورنال: Journal of Ankara Medical School
سال: 2005
ISSN: 1300-5464
DOI: 10.1501/jms_0000000012